4. 50 Cent vs. Ja Rule The masterpiece of 50 Cent's illustrious feuding career is his on-going beef with Ja Rule. The origins of the feud are disputed: Did 50's associate snatch Ja's chain in 1999? Or did Murder Inc. turn 50 away from a video shoot in Queens? We may never know, and at this point it doesn't matter; the pair's legacies are hopelessly intertwined. 50's first major hit, "Wanksta," was inspired by Ja Rule, and Ja's 2003 rebuttal, "Loose Change," earned him rare street approval. For a brief moment in the early- to mid-2000s, this beef was the hottest thing in hip-hop. Today, it has become tiresome. 50 continues to needle Ja over a variety of topics. The winner, it seems, will be whoever lives longest. 7. 50 Cent vs. The Game Above all else, 50 Cent is a businessman. Even in the mid-2000s, when his street cred was at its apex, fans wondered about the credibility of the rapper’s beef with West Coast rival The Game. Was it a media ploy to boost record sales? Officially, the feud started not long after The Game was placed in G-Unit by Aftermath Entertainment boss Dr. Dre. G-Unit was involved in a slew of running beefs, most notably with Ja Rule and his Murder Inc. label, and 50 Cent wasn’t happy with Game’s lack of participation. He also believed he wasn’t getting enough credit for his work on Game’s debut album, The Documentary. The situation quickly escalated. Shots were fired outside the Hot 97 studio in New York, injuring a member of The Game’s crew. After a brief truce, both sides unleashed a flurry of diss records, with Game’s 14-minute “300 Barz and Running” being the piece de resistance. The feud eventually ran out of steam, and 50 and The Game squashed it at the Ace of Diamonds Strip Club in Los Angeles in 2016. 12. Eminem vs. The Source Eminem has been involved in numerous feuds during his career, but none were as vicious or more personal than his beef with The Source magazine and its co-founder, Benzino. The once-friendly relationship (Eminem was the first white rapper to appear on the cover) turned sour after The Marshall Mathers LP received a middling review. Eminem voiced his displeasure; Benzino released a diss track; Eminem responded. The beef heated up in 2003 when Benzino released "Pull Your Skirt Up," in which he took credit for Em's meteoric success. Eminem replied with "Nail in the Coffin," a devastating diss eviscerating Benzino on a range of sensitive subjects. The s--t truly hit the fan when Benzino published an unreleased track on which Eminem made derogatory remarks about Black women. Em was forced to apologize publicly, but Benzino somehow got the worst of the exchange. He and The Source parted ways soon after. And both, The Source and Benzino went broke. 27. Dr. Dre vs. Uncle Luke In 1993, Dr. Dre’s cultural influence was nearing its apex. He was an originator of the G-Funk sound sweeping the airwaves from coast to coast, and a prominent figure in the simmering East Coast vs West Coast feud. That year, he released “Fuck with Dre Day (And Everybody’s Celebratin’),” featuring Snoop Dogg, which was a direct response to New York rapper Tim Dog’s “Fuck Compton.” “Dre Day” was not only a commercial success—it reached No. 8 on the Hot 100—but it contained blunt shots at a variety of targets, including former collaborators Eazy-E and Ice Cube, the aforementioned Tim Dog, and Uncle Luke from the 2 Live Crew. Luke took the insult to heart. He responded with “Cowards in Compton,” a track recorded alongside JT Money and Clayvoisie. The video parodied Dre’s stint with the World Class Wreckin’ Cru and featured Dr. Dre and Snoop Dogg lookalikes. Luke’s album, In The Nude, also included a skit titled “Dre’s Momma Needs a Haircut.” 32. Eminem vs. Machine Gun Kelly This was a sizzling feud that divided people who bleached their hair 20 years ago and people who bleach their hair today. Officially, it started when Eminem dissed Machine Gun Kelly on the song “Not Alike” off Kamikaze. Unofficially, it started six years earlier, in 2012, when Kelly tweeted that Eminem’s daughter was hot. Kelly’s response, “Rap Devil,” suggested that Eminem is old and uncool. Em’s almost-instantaneous rebuttal, “Killshot,” claimed that Kelly was untalented and incapable of matching his success. MGK ended moving into completely other genre of music. 33. Royce da 5'9" vs. D12 Royce da 5’9” and Eminem have worked together for decades, since their respective beginnings in the Detroit rap scene. That didn’t stop Royce from feuding with Em’s D12 collective in the early 2000s. The rapper released three diss tracks against the squad: “S--t On You,” which focused on D12 member Bizarre; “Malcolm X”; and “Death Day.” D12 responded with “Smack Down,” and member Proof (R.I.P.) added the solo track “Many Men.” He also collaborated with the Purple Gang on a third diss track, “Beef is Ova.” The feud culminated in a confrontation outside a Detroit nightspot. Proof and Royce’s entourages clashed and the two rappers were arrested. They were placed in adjacent cells where they managed to squash the dispute. After a brief flareup in 2007, the beef was officially called off in 2008 when Royce appeared on two D12 mixtapes. For the full list, visit COMPLEX.